Big Dreams Grant

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to 3 years support for studies to replicate the impact of the natural product on target engagement when used by humans, and assess whether there is an association between the degree of the impact on target engagement and functional or clinical outcomes in a patient population. Applications are encouraged to design studies to determine how to optimize the impact of the natural product on target engagement by optimizing the delivery of the natural product through examination of different doses or formulations. In addition, applications can be designed to combine the natural product with another treatment approach that is known to engage the same target; or study the impact of the natural product in a target population that is more responsive. Clinical trials submitted under this NOFO are expected to be hypothesis based, milestone-driven, and directly related to the research priorities and mission of NCCIH. This R33 funding mechanism is intended to accelerate the translation of emerging basic science findings about natural products into early-stage clinical testing to determine whether continued clinical research is warranted. This NOFO will not support efficacy or effectiveness trials, nor will

The Business Stabilization Fund for French Quarter Businesses provides financial assistance grants of up to $2,500 (for businesses with fewer than 8 employees) or up to $5,000 (for businesses with 8 or more employees) to small businesses in New Orleans' lower French Quarter that have experienced demonstrable revenue losses due to prolonged infrastructure construction. Administered by the Greater New Orleans Foundation through its 501(c)(3) subsidiary the New Orleans Community Support Foundation, with support and assistance from the City of New Orleans, the pilot program is designed to stabilize the French Quarter's commercial corridors during a period of major infrastructure improvement, maintain sales tax revenue from threatened businesses, protect jobs at impacted businesses, and prevent urban decay along construction-disrupted blocks. Eligibility is geographically limited to active, public-facing businesses fronting the 900, 1000, 1100, 1200, and 1300 blocks of Decatur Street or the 600 block of St. Peter Street. To qualify, applicants must have continuously owned and operated a business at a qualifying address since January 1, 2025, demonstrate a revenue decrease reasonably attributed to the construction project, be registered and in good standing with the Louisiana Secretary of State, hold an active City of New Orleans Occupational License, and have sales tax remittance equal to or exceeding the assistance amount requested. Businesses that consist entirely or primarily of property ownership, management, or rent collection within the project boundaries are not eligible, as the program is focused on supporting active, public-facing businesses rather than commercial landlords. Nonprofits without commercial activity that generates sales tax for the City of New Orleans, corporate-owned franchises, and businesses owned by employees (or immediate family of employees) of the City of New Orleans or the French Quarter Management District are also ineligible. Final award amounts may be lower than the maximums depending on funding availability and the total number of eligible applicants.

The SafetyWorks Training Grant provides Massachusetts-based employers with up to $25,000 in funding for employee training that prevents or addresses workplace injuries and illness. Also known as the Workplace Safety Grant, the program is administered by the Office of Safety within the Massachusetts Department of Industrial Accidents (DIA) and supports a wide range of hands-on, in-person safety training topics, including emergency response and first aid, workplace violence prevention and de-escalation, fire and electrical safety, fall protection, hazardous materials handling, confined space and rescue, and regulatory compliance, among others. The grant operates as a reimbursement program: training must be pre-approved and conducted under a signed contract before any costs become eligible, and all training must be delivered by Massachusetts-based trainers. Applications are accepted on a rolling basis but training and funding must occur during announced funding cycles.

The Asheville Recovers Together Grant provides Asheville, North Carolina small businesses impacted by Tropical Storm Helene with reimbursement grants of $5,000 to $75,000 to support recovery and ongoing operations. Funded by the City of Asheville and jointly administered by ArtsAVL, Eagle Market Streets Development Corporation, and Mountain BizWorks in collaboration with community partners across the city, the program is designed to help local businesses stabilize, recover, and grow following the storm's economic impact. Grant funds may be used for payroll, rent and utilities, inventory, supplies and equipment, marketing, and other eligible business operating expenses, and may also support efforts to rehire staff, replace lost inventory, add jobs, or launch new products and services. Eligible applicants must have a primary location within Asheville city limits, have been operating before September 27, 2024, have experienced financial losses due to Hurricane Helene that were not fully covered by insurance or other funding, have owners who are legal U.S. residents, have generated at least $20,000 in revenue in one of the last three years, and be currently open or have a plan to reopen. Businesses must also be in good standing with no active bankruptcies, tax liens, or federal funding bans. Nonprofits, cannabis-related operations, passive real estate or investment holdings, political or lobbying organizations, adult entertainment businesses, corporate-owned national franchises or chains, and residential short-term rentals are not eligible. Awards are issued as reimbursements, requiring applicants to pay eligible expenses upfront and then submit receipts or proof of payment for review and approval.

The EDGE Grant Competition is the Division’s flagship funding program aimed at helping young Delaware small businesses grow and scale. The program awards grant funds through a highly competitive selection process and pitch competition. Ten or fewer businesses in the Entrepreneur (general business) category will receive funding from a pot of $400,000, and eight or fewer businesses in the STEM category will receive funding from a $750,000 pot.