Denver Business Impact Opportunity Fund

The Wyoming Business Council Market Expansion Grant (MEG) helps defray costs for private Wyoming-based for-profit businesses participating in market expansion activities. The primary focus of this grant is to assist businesses in overcoming challenges associated with expanding into new markets outside Wyoming. Companies must be in good standing with the Wyoming Secretary of State, with an annual revenue of less than $5,000,000.

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated mid-phase clinical trials of natural products(i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. All applications submitted under this NOFO must be supported by sufficient preliminary data demonstrating bioavailability (if applicable) and documentation that the natural product produces a reproducible and measurable impact on target engagement (i.e., measure of the mechanism of action). Only in cases when it is not possible/practical to measure target engagement in the patient population of interest or when there is a fundamental understanding of the products mechanism of action will this preliminary data requirement be waived. Applications submitted to this NOFO should propose a mid-phase clinical trial to do the following: determine the optimal dose or formulation of a given natural product for use in a future multi-site efficacy trial; or determine which patient phenotypes will be responders versus non-responders to the natural product to inform inclusion/exclusion criteria of a future efficacy trial. Clinical trials submitted under this NOFO are expected to be hypothesis based, milestone-driven, and directly related to the research priorities and mission of NCCIH. This NOFO will not support single-site or multi-site efficacy or effectiveness trials, nor will it support trials to test natural products for the treatment or prevention of cancer. Applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NO

The Houston Texans Small Business Boost provides selected Greater Houston small businesses with a $5,000 grant along with marketing and promotional support designed to raise the winner's visibility across the city. Created in 2020 as a partnership between the Houston Texans and Amegy Bank, the program recognizes independently owned, for-profit businesses based primarily in the Greater Houston area. In addition to the cash grant, winners receive a feature on HoustonTexans.com (including a dedicated web article and a social media post announcing the win), access to event opportunities through Amegy Bank, and a commemorative plaque presented by the Texans and Amegy. Businesses are nominated for the award, and multiple winners are selected each year.

The Venture Pitch assistance micro-grant can reimburse up to $5000, spent on hiring an independent, third party to assist in the creation of an investor pitch deck, assemble a researched list of at least 5 investors to contact that includes the investor profile, the investment criteria, their portfolio, news releases of companies they invested in and create an advanced and well thought out financial and P&L model with market size, costs, pricing, sales key assumptions. To be eligible for this grant, applicants must have received a Phase I or Phase II SBIR/STTR award.

The Greater Dallas County Development Alliance has officially opened applications for the next round of its Small Business Grant Fund, which provides monetary support to small businesses in the Dallas County area. The grant program, which launched last year, aims to fund applicants looking for financial assistance in key growth areas such as furniture and fixtures, technology, marketing, and professional development. A total of $20,000 in funding is available, and applications are open from April 1 through May 31. Last year, five small businesses representing a range of industries were awarded funding through the program.