San José Small Business Start-Up Grant

The Signage Improvement Program is a grant available to developers, business, and commercial building owners in Oxford, AL that wish to improve their signage. The program is divided into two types of funding for either a “brick and mortar” business or a mobile unit. The “brick and mortar” fund has a total pool of $7,000 and the mobile unit has a total pool of $3,000. The program is a 70/30 grant that may not exceed the amount of $1,000 per address, per year for the “brick and mortar” category and mobile units may not exceed the amount of $500 per unit, per year for the “mobile unit” category. Applicants may not apply for both, but only one category.

This program provides matching grants for research and development activities in partnership with a Nebraska college or university. Eligible businesses include for-profit companies that have physical operations in Nebraska. Phase I awards go up to $100,000, while Phase II awards are capped at $400,000. Funding can be used to commercialize new projects, modify existing products for better marketability, and improve processes to create revenue streams for Nebraska businesses.

Now in its third year, this grant program will award 40 small businesses $5,000 each and two Grand Prize winners $20,000, fueling expansion, innovation, and long-term success across Nassau and Suffolk Counties. Small businesses with locations in Nassau or Suffolk Counties and 10 or fewer employees can apply.

The Spectrum Reach Pay It Forward Grant program provides small business owners with marketing resources and tools to expand their brand, connect with new audiences and achieve lasting success. Grant recipients will receive free TV and streaming advertising, an original 30-second commercial, support from local marketing experts in the community, on-demand educational resources and top-level industry insights and opportunities to network and learn at invitation-only events with peers.

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated mid-phase clinical trials of natural products(i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. All applications submitted under this NOFO must be supported by sufficient preliminary data demonstrating bioavailability (if applicable) and documentation that the natural product produces a reproducible and measurable impact on target engagement (i.e., measure of the mechanism of action). Only in cases when it is not possible/practical to measure target engagement in the patient population of interest or when there is a fundamental understanding of the products mechanism of action will this preliminary data requirement be waived. Applications submitted to this NOFO should propose a mid-phase clinical trial to do the following: determine the optimal dose or formulation of a given natural product for use in a future multi-site efficacy trial; or determine which patient phenotypes will be responders versus non-responders to the natural product to inform inclusion/exclusion criteria of a future efficacy trial. Clinical trials submitted under this NOFO are expected to be hypothesis based, milestone-driven, and directly related to the research priorities and mission of NCCIH. This NOFO will not support single-site or multi-site efficacy or effectiveness trials, nor will it support trials to test natural products for the treatment or prevention of cancer. Applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NO