WI Venture Pitch Readiness Micro-Grant

This program helps businesses grow and modernize by offering a 50/50 match on eligible equipment purchases. Elligible businesses can receive up to $20,000 in matching grant funds.

The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics. These tools will be critical for developing treatments such as closed loop systems for brain disorders including Parkinsons disease and major depressive disorder.

The Innovation Voucher program is part of Rhode Island Commerce’s Innovation Initiatives Portfolio created to support Rhode Island’s small businesses and entrepreneurs. The Innovation Voucher funds strategic investments in local businesses that catalyze growth through research and development (R&D) innovation. There are two types of vouchers in this program, both for $5,000 to $75,000. Knowledge Provider Voucher: The Knowledge Provider Voucher helps small businesses tap the expertise and resources of local research institutions such as colleges, universities and hospitals (“knowledge providers”) to advance innovation and business growth. With a Knowledge Provider Voucher, the R&D needed by a small business is executed by the knowledge provider. Manufacturing Voucher: Rhode Island manufacturers can access funding for internal research and development through the Manufacturing Voucher. This voucher supports specific R&D projects that Rhode Island manufacturers need to advance or reinvent their product offerings and remain competitive within their industry.

Businesses in Danville can receive partial reimbursements up to $5,000 for making improvements to their storefronts and building exteriors.

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated mid-phase clinical trials of natural products(i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. All applications submitted under this NOFO must be supported by sufficient preliminary data demonstrating bioavailability (if applicable) and documentation that the natural product produces a reproducible and measurable impact on target engagement (i.e., measure of the mechanism of action). Only in cases when it is not possible/practical to measure target engagement in the patient population of interest or when there is a fundamental understanding of the products mechanism of action will this preliminary data requirement be waived. Applications submitted to this NOFO should propose a mid-phase clinical trial to do the following: determine the optimal dose or formulation of a given natural product for use in a future multi-site efficacy trial; or determine which patient phenotypes will be responders versus non-responders to the natural product to inform inclusion/exclusion criteria of a future efficacy trial. Clinical trials submitted under this NOFO are expected to be hypothesis based, milestone-driven, and directly related to the research priorities and mission of NCCIH. This NOFO will not support single-site or multi-site efficacy or effectiveness trials, nor will it support trials to test natural products for the treatment or prevention of cancer. Applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NO