CT Innovation Voucher Program

This Notice of Funding Opportunity (NOFO) invites applications that propose to use mouse models to conduct rigorous preclinical testing of drugs or drug combinations currently used for other conditions, as well as investigational drugs at various stages of clinical development, predicted to be efficacious in AD/ADRD. This initiative will also support preclinical testing of repurposable or investigational drug candidates in combination with non-pharmacologic interventions leading to robust translational outcomes. The central goal is to establish robust proof of concept that will enable rational drug repurposing and combination therapy development for the treatment and prevention of AD/ADRD.

Purpose: This grant provides resources for keeping boater sewage from California waterways. Description: The Pumpout Facility Grant Program funds the construction of pumpout and dump stations on California's waterways.

This grant supports early-stage socio-technical partnerships focused on research data infrastructure ecosystems. The Cyberinfrastructure for Public Access and Open Science (CI PAOS) program within the Office of Advanced Cyberinfrastructure (OAC) aims to catalyze new and transformative socio-technical partnerships supporting research data infrastructure ecosystems across domains through early-stage collaborative activities between cyberinfrastructure researchers, scientists, research computing experts, data management experts, research labs, university libraries, and other communities of practice. The CI PAOS program supports the NSF Public Access Initiative by encouraging innovation across the CI ecosystem to address accessibility, discoverability, reliability, reproducibility, sustainability, and utility of data products in alignment with NSF and national goals for public access and open science. NSF accepts proposals pursuant to this Program Description year-round. From time to time, NSF may also issue Dear Colleague Letters to encourage proposals on special thematic interests and opportunities related to this program.

The Biosensing program is part of the Engineering Biology and Health cluster, which also includes 1) the Biophotonics program; 2) the Cellular and Biochemical Engineering program; 3) the Disability and Rehabilitation Engineering program; and 4) the Engineering of Biomedical Systems program. The Biosensing program supports fundamental engineering research in the monitoring, identification and/or quantification of biological analytes and phenomena using innovations that exist at the intersection of engineering, life sciences, and information technology. Projects submitted to the program must advance both engineering and life sciences. The Biosensing program encourages proposals that, in addition to advancing biosensing technology, address critical sensor needs in biomedical research, public health, food safety, agriculture, forensics, environmental protection, and homeland security. Proposals are especially encouraged in areas of critical need: sensing technologies that can enable monitoring and surveillance of the environment and/or individuals for novel infectious agents; platform technologies that can readily be modified as soon as new agents are detected, sequenced, and/or otherwise characterized to enable rapid deployment of sensors in clinics and the environment; and adaptive and/or multiplex sensing technologies that can help the nation prevent the spread of the next global pandemic. Major areas of interest for the program include: -Novel signal transduction principles and mechanisms that enable sensitive and specific biosensors, suitable for measurements in multiple areas; -Design of novel biorecognition elements and appropriately designed transducing systems to enable adaptable and/or reconfigurable operating parameters in response to environmental changes or application needs at levels of device, system, or data analysis; -Development of adaptive and/or evolvable biosensing systems for detection of novel target analytes or analytes under novel conditions; -Novel synthetic biology approaches for the development of cell-free and cell-based biosensors; and -Combining biosensors with artificial intelligence (AI) methods to improve sensor specificity and response time.

Purpose: The Pollution Control Tax-Exempt Bond Financing Program facilitates low cost capital through private activity, tax-exempt bonds. The securities pay for acquisition, construction or installation of qualified pollution control, water furnishing, waste disposal, waste recovery facilities and equipment. Tax-exempt bond financing assists qualified borrowers to obtain lower interest rates than are available through conventional loans. Description: CPCFA acts as a conduit issuer in the transaction. The bonds are issued to raise capital for revenue-generating projects where the funds are used by the borrower to make payments to investors. The conduit financing is typically backed by either the borrower's credit or monies pledged to the project by outside investors. If the project fails and goes into default, it is solely the borrower's responsibility to repay the bondholders.