Worcester Small Business Grant Program

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated mid-phase clinical trials of natural products(i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. All applications submitted under this NOFO must be supported by sufficient preliminary data demonstrating bioavailability (if applicable) and documentation that the natural product produces a reproducible and measurable impact on target engagement (i.e., measure of the mechanism of action). Only in cases when it is not possible/practical to measure target engagement in the patient population of interest or when there is a fundamental understanding of the products mechanism of action will this preliminary data requirement be waived. Applications submitted to this NOFO should propose a mid-phase clinical trial to do the following: determine the optimal dose or formulation of a given natural product for use in a future multi-site efficacy trial; or determine which patient phenotypes will be responders versus non-responders to the natural product to inform inclusion/exclusion criteria of a future efficacy trial. Clinical trials submitted under this NOFO are expected to be hypothesis based, milestone-driven, and directly related to the research priorities and mission of NCCIH. This NOFO will not support single-site or multi-site efficacy or effectiveness trials, nor will it support trials to test natural products for the treatment or prevention of cancer. Applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NO

The Kansas Department of Commerce and Kansas Office of Registered Apprenticeship (KOA) has realized significant growth in high-wage and high-demand occupations, but there still remains a significant need to engage small businesses essential to the state economic success. This grant specifically targets small businesses with less than 10 full-time employees, and will provide $7,000 one-time grants to support the registration of New Apprentices in high-wage and high-demand occupations.

The Halstead Grant is an annual award for emerging silver jewelry artists. Applicants submit answers to 15 business questions in addition to their design portfolios. The experience is designed to help jewelry entrepreneurs create a strategy to kick-start their careers. The grand prize is a $7,500 cash grant plus other benefits.

The AI MicroGrant Program is designed to support startups and small businesses who need small amounts of financial assistance to implement or integrate AI components in their business operations that ultimately lead to broad adoption of AI in the community.

The Oklahoma Department of Commerce is offering a jobs program that refunds employers up to 10% of an employee’s net benefit rate for up to 10 years. Applicants in target industries must commit to creating 10 new direct jobs. New jobs are roles in qualifying industries that did not exist in the state in the prior six months. Employer compensation begins at 7% and increases to 10% once all 10 of the new roles are hired.